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Layerform™

LayerForm™ is a proprietary coating process that stably incorporates drugs from water into a thin polymer film atop a substrate surface (anything from a prosthetic device to nanoparticles). The coating is generated as polymers and drugs self-assemble onto the substrate via complementary electrostatic interactions one molecular layer at a time. In a physiologic environment, the coating degrades in a controlled manner, delivering its therapeutic payload to target tissue.  LayerBio is developing this technology for a variety of regenerative medicine applications, including:

layerform™ Benefits

Tunability. Precise control of dosing and release. PK profiles from minutes to months. Drug loading densities as much as 50% by weight.

Drug Stability. Gentle, aqueous process eliminates potential for drug denaturation. Labile drugs are stably complexed with LayerForm polymers  protecting drugs against degradation in vivo.

Biocompatibility. Coatings comprise degradable polymers with proven safety and biocompatibility.

Modular Platform. Compatible with small molecules, biologics, and nucleic acids. Capable of combination therapies with staged release profiles.

Effective transfection of nucleic acids. Polyplexes of LayerForm polymers with nucleic acids facilitate uptake into cells.

Manufacturing and Scale-up. Process is readily scalable for manufacturing using industry-standard equipment.

  LayerForm™ Drug Coatings Atop Various Substrates . A. Nylon mesh, B. PLA microspheres, C. Porous PLGA , and D. Freestanding film (removed from substrate).

LayerForm™ Drug Coatings Atop Various Substrates. A. Nylon mesh, B. PLA microspheres, C. Porous PLGA , and D. Freestanding film (removed from substrate).